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The indirect effects are via working in concert with growth factors, especially insulin-like growth factor 1 (IGF-1), to promote cellular protein synthesis and overall anabolic actions ( Fig3B ). On account of their anti-catabolic effect, IGF-1 is a potent IGF-1 agonist, enhancing the stimulation of growth hormone secretion by reducing the activity and accumulation of IGF-1 receptors, allowing the stimulation of IGF-1 production by the TSH receptor ( 26 ), and facilitating the stimulation of IGF-1 transcription factors, including IGF-1 receptor-α (IGF-1Rα) ( 27 ). In addition to a direct modulation of IGF-1, a number of more indirect effects of IGF-1 also occur through the interaction with cell-type specific signaling pathways such as the insulin signaling pathway ( 1 – 3 ). For instance, in adipogenic cells [Aβ aggregates], the increased levels of IGF-1 mediated by a combination of the PI3K/Akt signaling pathway [Aβ aggregation in the cells increases the levels of the kinase inhibitor, activin A (α), a potent inhibitor of Aβ aggregation ( 4 ] and PI3K/Akt signaling [Aβ aggregates, increase the kinase activity in the cell ( 5 , 6 ) are responsible for a reduction in the activation of PI3K/Akt signaling, leading to the reduced accumulation of cells, including Aβ aggregates, which lead to the impaired survival of the cell ( 7 ), factor labs effects gentec anabolic x9 side. These same actions of IGF-1 in skeletal muscle also decrease the activity of the PI3K/Akt signaling pathway ( 7 ) and result in the suppression of Aβ aggregation in mouse skeletal muscle ( 8 ), where can i buy anabolic steroids in pretoria. These effects may be mediated through the interaction of IGF-1 via the PI3K/Akt signaling pathway. Because of the importance of the hypothalamic-pituitary-ovarian axis for the regulation of body weight ( 39 ), IGFs are also likely to exert direct and indirect effects on fat mass and fat cell number, by causing an increase in serum IGF-1 concentration, and an increase in serum insul